The most potent and fast-acting Rasaaushadhis (metal-mineral preparations) have been repeatedly criticized for their heavy metal toxicity. To rule out this myth in scientific era Vanga sindoora sagandha bahirdhuma kupipakwa rasayana (rejuvenating traditional preparation using a glass bottle and  purified forms of tin, sulphur and others as ingredients) which possesses qualities like Deepana (appetizer), Balya (strenhening), Dhatusthairykara (tissue rebuilding), Sarva prameahahara(anti diabetic), was selected and prepared as per the classics and assessed for nephroprotective efficacy in gentamicin induced nephrotoxicity protocol in Wister strained albino rats. The assessment was done by analyzing blood parameters S.Urea, S.creatinine, S.electrolytes and histopathological study of kidneys. The data was analysed by one way Annova test. The results of the test group showed a significant improvement in renal function in both hematological and histological reports compared to the standard group. Vanga sindoora dose of 2.25 mg/0.2kg (Human Dose 125 mg) was more effective than the Vanga sindoora group dose 4.5 mg/0.2kg (Human Dose 250 mg) and had the best Nephro Protective effect.