Department of Haematology and Blood Transfusion,
University of IlorinTeaching Hospital, Ilorin,
PMB 1459, Kwara State, Nigeria.
Ionizing radiation is one of the most important
modalities for the treatment of human
malignancies. Acute and chronic toxicities with
severe morbidity and mortality are well
documented because it is not tumor specific.
This disability also limits the role of
radiotherapy in cancer treatment. Experimental
and clinical approaches to correcting radiation
haemopoietic syndrome deficiencies have focused
on cytokine activity. Such treatments are not
without certain risks. There has been an upsurge
of interest on the effects of various dietary
insufficiencies on haemopoietic and immune
responses in recent years. Limited data is
available on differentiation enhancing effects
of plant extracts on haemopoietic stem cells
following radiation injury. This study aimed to
determine the potential differentiation effects
of
Telfairia occidentalis
on guinea pig marrow haemopoietic multi-stem
cells following irradiation. Bone marrow cells
from irradiated guinea pigs were harvested and
treated with varying concentrations of 0.313 to
100% of the extracts of the T.
occidentalis
and the degree of differentiation of the
cultured guinea-pig bone marrow haemopoietic
stem cells determined. The extract concentration
ranges of 0.313 to 100% showed significant
statistical difference in differentiation
[p=0.000] when compared to the control. There
was also strong positive correlation [r= 0.812;
p=0.001] between the concentration of the
extracts of the T.
occidentalis
and the degree of differentiation of bone marrow
haemopoietic stem cell. Analysis of the cell
expression though uncoordinated during cell
differentiation is more in favour of erythroid
lineage. T.
occidentalis
extract has positive differentiation enhancing
effects on haemopoietic multi-potent stem cells.
The differentiation effect correlates with the
concentration of the plant extract and deflect
in favour of erythroid lineage.
This is an open access article
published under the terms of the
Creative Commons Attribution
License, which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is
properly cited.
Cite this article as: Olatunbosun LO, Khalil EAG,
Olalere FD, Lawal SA, Biliaminu SA, Ogunwale KAT, Shittu AO, Babatunde AS, Rasaq
RA, Abdul-Raheem OJ, Afolabi OO (2018). Haemopoietic multi-stem cells
differentiation enhancing effect of Telfairia occidentalis extract. J. Biol.
Ser. 1(2): 042-047.
