An evaluation of collagen
peptide for transdermal delivery using Strat-M® membrane and
excised mouse skin.
Accepted 16th February,
2024
Zheng Yan1,
Peng Dong1,2*, Bin Jiang1, Xiao-Qing Zhang2,
Li-Ge Liu2, and Hai-Yan Wang2
1College of Bioengineering, Beijing Ρolytechnic, Beijing 100176,
China. 2Beijing Semnl Biotechnology Co., Ltd., Beijing 100062, No. 9,
Street 1, Liangshuihe, Development Area, Beijing 100176, China.
In the field of medicine and cosmetics, transdermal experiments are commonly
used to evaluate the transdermal absorption of topical formulations. In this
study, we applied Strat-M® membrane to investigate the in vitro transdermal
properties of collagen peptide with different average molecular weight, and
compared them with the transdermal absorption through excised mouse skin
in vitro.
The results showed that the transdermal rate of collagen peptide through Strat-M®
and excised mouse skin increased linearly with time, and the different
concentrations of collagen peptide solutions affected the final cumulative
transmission. The cumulative transmission per unit area of collagen peptides
through Strat-M® had a good correlation with that through excised mouse skin,
R2> 0.98. Strat-M® can replace the excised mouse skin in vitro to carry out the
transdermal experiment of collagen peptide.
Key words: Scarcity, shortages, leaks, framing,
mediatization.
This is an open
access article published under the terms of the
Creative
Commons Attribution License, which permits unrestricted use,
distribution, and reproduction in any medium, provided the
original work is properly cited.
Cite this article as:
Yan Z, Dong P, Jiang B, Zhang
X-Q, Liu L-G, Wang H-Y
(2023). An evaluation of collagen peptide for transdermal delivery using Strat-M®
membrane and excised mouse skin. 11(1):
001-008.
